PCR Test Cannot Differentiate Between Seaonal Influenza and COVID-19

It was pointed out that the CDC said that the PCR test cannot differentiate between seasonal influenza and COVID-19 – but the PCR test does not test for seasonal influenza at all.

Possible concerns

Antibody Depenent Enhancement (ADE)

What is ADE? Antibodies are supposed to prevent cell entry – but on rare occasions they can actually increase the ability of a virus to enter cells. This is called antibody-dependent enhancement (ADE). Article. Article. This consideration must be taken into consideration when developing COVID vaccines. Unfortunately in testing, most animal models and in vitro models seldom predict ADE, thus we need more studies to define the clinical correlation with protective immunity. We need to carefully analyze the safety of mRNA vaccine in humans because ADE of diseases cannot be predicted after administrating antibodies and vaccination.

Researches of mRNA vaccines against bacteria and parasites are limited. No vaccine relating to bacteria and parasites has been approved so far. As for bacteria, they are one hundred times larger than viruses. Hence, there are differences in the structural complexity and immunology between them. Although mRNA vaccines in tumors and viruses have multiple advantages, they are still in the initial stage. Currently, safety is the most significant issue. ADE should be considered in developing mRNA vaccines.

Speaking to ADE, Brian Lichty, PhD, an associate professor in pathology and molecular medicine at McMaster University in Toronto, spoke with Medpage Today, who published,

“To date, there’s really no evidence of ADE with the COVID-19 vaccines. It’s all theoretical,” he said. “I think all the evidence so far is that ADE is not turning out to be a problem with any existing vaccines or viral variants.” One reason could be that SARS-CoV-2 just may not affect macrophages in a way that can produce ADE, although scientists are still working out the details. ADE has been reported after natural infection with other viruses, such as HIV, Ebola, and coxsackievirus, as well as other coronaviruses like SARS and MERS. Throughout the pandemic, scientists have been looking for ADE associated with SARS-CoV-2, but so far they haven’t found any cases of it, noted Lichty. “This coronavirus may already be sufficiently adapted to humans, so that if it does get into macrophages via a non-neutralizing antibody interaction, it may not allow the macrophage to produce enough cytokine to cause an obvious pathology,” he said.

From what I am reading, more time is required, however at the moment it seems to not be of much concern.

Viroprons

Viroporins are small multifunctional viral proteins (~ 60–120 amino acids) that modify cell membranes, thereby facilitating virus release from infected cells. Viroporins are capable of assembling into oligomeric ion channels or pores in the host cell’s membrane, rendering it more permeable and thus facilitating the exit of virions from the cell. Many viroporins also have additional effects on cellular metabolism and homeostasis mediated by protein-protein interactions with host cell proteins. Viroporins are not necessarily essential for viral replication, but do enhance growth rates. Their absence does weaken or attenuate the virus and diminishes its pathogenic effects. Viroporins are sensitive to changes in the cellular environment. The charge on the lipid head group of membranes can modulate the ion-selectivity of the viroporin. Recent efforts have been directed toward understanding how mutant CoV E viruses carrying ion channel-inactivating mutations revert to their original pathogenic state. While some of these mutations appear to merely restore the loss of ion channel activity, it is not entirely inconceivable that revertant viruses could acquire gain of function mutations rendering it more virulent. Viroporins are common to RNA viruses, such as COVID-19. Article.

Fact or Fiction?

Statements purported to have been spoken by Nobel Prize winner Luc Montagnier

Fiction

Fact

While reading some Fact Check articles I understood and agreed that the above quotations were not true. That said, the nobel prize winner did speak to his opposition to mandatory vaccinations in France and drew criticism from fellow academics for broadcasting what they cconsidered to be “dangerous messages”.  And in an interview posted online Montagnier claimed that the vaccines have produced new coronavirus variants and that “the curve of vaccination is followed by the curve of deaths“, thanks to “antibody dependent enhancement,” (ADE) which he says can create more severe disease.

COVID-19 Shedding

Fiction

You can get COVID-19 from someone who has been vaccinated, through a process called Shedding.

Fact

It is not possible for this to occur, as none of the vaccines have the COVID-19 virus in it (active or deactivated). Luigi Warren, tweeted regarding that the mRNA solutions could cause those vaccinated to shed the spike protien that is created. Twitter deleted the tweet, to which he responded that he is “the inventor of the technology on which Moderna was founded”, implying that he might just know what he’s talking about. While this seems to remain in question, as it has been contested by other scientists, Luigi supported that the shedding would be miniscule and would not affect others. So essentially, this is a mute point.

My Questions

Vaccine vs Treatment

Question: Essentially I am to understand that a vaccine is medically and legally defined as serving two purposes: to stimulate both an immunity in the person receiving it and to disrupt transmission. Questions as to whether these mRNA solutions are actually Vaccines has arisen.
Answer: In what I read, depending on whose definition used it might be classified as a device. While this will stimulate an immuno-response in the body it will not induce an immuno-transmissive response (it does not disrupt transmission of the virus).
Question: This leads me to wonder if people are looking for a way to bypass the exemption these vaccine manufacturers have been offered (by the government) to ensure they are not responsible for any deaths?

Possible side-effects:
Question: I read that studies have shown that the expression of the pathogenic envelope being generated by the cells (the expression of that piece of the virus now being created by the body) are known as leading to / linked to conditions such as; multiple sclerosis, Lou Gehrig’s disease, Alzheimer’s, and accelerated cancers. Is this factual in any way – speculation – or simply information that has been falsified?
Answer: It seems that I am having troubles finding these studies. Perhaps they were ‘buried’? Perhaps they do share some similarities? I’ll keep looking – out of interest – as nobody seems willing or able to answer this question yet.

The auto-immune response:
Question: This is a question I’ve never seen asked, but it makes me wonder as to if this explains some of the extreme adverse effects posted, is what happens if the body cannot destroy the cells that, per the delivery method, have now been re-programmed to make the pathogenic portion of the virus in the body? Does the person carry this as a problem with them forever? Is there a way to re-program the cells again – return them back to normal? How is this problem detected?
Answer: As I’ve read – it seems that the body does not continue to manufacture this after a period of approximately 2 days. I’m looking into why now.

While I’ve had to answer many of my own questions, I am hoping someone can shed some light on those above that have not yet been answered.

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